Journal: Infection

Article Title: Clinical outcomes of hospitalized COVID-19 patients treated with remdesivir: a retrospective analysis of a large tertiary care center in Germany

doi: 10.1007/s15010-022-01841-8

Figure Lengend Snippet: Baseline characteristics of in-patients with COVID-19 treated at Hospital St. Georg in the period from July 1, 2020 to June 30, 2021

Article Snippet: Of the remaining 839 patients, 515 received corticosteroids (primarily dexamethasone) either as monotherapy or in combination with remdesivir, 260 patients received no additional COVID-19 drug therapy (apart from SOC), and 44 patients received remdesivir as monotherapy (Fig. ).

Techniques: Infection, Filtration

Journal: Infection

Article Title: Clinical outcomes of hospitalized COVID-19 patients treated with remdesivir: a retrospective analysis of a large tertiary care center in Germany

doi: 10.1007/s15010-022-01841-8

Figure Lengend Snippet: Age pyramid with differentiation by COVID-19 waves and disease severity (mild disease = WHO score 4, severe disease = WHO scores 5–7)

Article Snippet: Of the remaining 839 patients, 515 received corticosteroids (primarily dexamethasone) either as monotherapy or in combination with remdesivir, 260 patients received no additional COVID-19 drug therapy (apart from SOC), and 44 patients received remdesivir as monotherapy (Fig. ).

Techniques:

Journal: Infection

Article Title: Clinical outcomes of hospitalized COVID-19 patients treated with remdesivir: a retrospective analysis of a large tertiary care center in Germany

doi: 10.1007/s15010-022-01841-8

Figure Lengend Snippet: Clinical outcomes in the study population, including subgroups

Article Snippet: Of the remaining 839 patients, 515 received corticosteroids (primarily dexamethasone) either as monotherapy or in combination with remdesivir, 260 patients received no additional COVID-19 drug therapy (apart from SOC), and 44 patients received remdesivir as monotherapy (Fig. ).

Techniques:

Journal: Journal of Virology

Article Title: Development of a Fluorescence-Based, High-Throughput SARS-CoV-2 3CL pro Reporter Assay

doi: 10.1128/jvi.01265-20

Figure Lengend Snippet: Figure 1. A FlipGFP protease reporter with coronavirus cleavage sites fluoresces after 445

Article Snippet: The TEV control FlipGFP (Addgene 260 #124429) was designed to include a silent NheI restriction site ahead of the TEV cleavage 261 sequence and generated using a gBlock (IDT) (Fig. S1) with primers FlipGFP For and FlipGFP 262 Rev (Table S1) for insertion into BamHI and NotI digested pLEX.

Techniques:

Journal: Nature Communications

Article Title: Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation

doi: 10.1038/s41467-021-27723-5

Figure Lengend Snippet: a Principal component analysis of lung tissue of COVID-19 ( n = 11) compared to non-COVID-19 ( n = 3) decedents. Each dot corresponds to a single sample based on RNA‐seq data. b The differential genes expression between COVID-19 and non-COVID-19 of lung tissue, the vertical baseline represents the absolute value of log 2 fold change >1, and the horizontal baseline above represents p < 0.05. DESeq2 was used for differential gene expression analysis. c Gene set enrichment analysis of hallmark lymphocyte inhibitory genes based on non-COVID-19 to COVID-19. FDR < 0.05 defined as significant. Gene sets are ranked by the difference in the fraction of experiments with significant positive and negative enrichment. d Principal component analysis of bulk transcriptomes of lung (green, women = 7, men = 4), heart (yellow, women = 1, men = 1), kidney (purple, women = 1, men = 1), liver (red, women = 2, men = 2) and spleen (blue, women = 1, men = 1). e Comparison chemokine expression levels between men and women in lung, heart, kidney, liver and spleen. Colored according to the sample based on RNA‐seq data. f Gene Ontology analysis of pathways enriched of multiple organs in women upregulate compared to men. Colored according to the sample based on RNA‐seq data. Fisher’s exact test. Source data are provided as a Source Data file.

Article Snippet: The DESeq2 (v1.26.0) and edgeR (v3.28.1) package in Rstudio ( https://rstudio.com/ ) was used to identify differentially expressed genes.

Techniques: RNA Sequencing, Expressing, Gene Expression, Comparison